Co-Amoxyclav Injured my Liver
Grrr… Now I’m mad. I know these damn anti-biotics were harmful, I just did not know they were THAT harmful. The real reason for my liver malfunction which is manifested in my rashes is because this is a side effect of the anti-biotics coamoxyclav I took to battle the infection caused by my chemical burns.
The analysis in the paper hits it right on the money:
http://pearl.sums.ac.ir/semj/vol2/jul2001/liver&coamoxy.htm
Combination of Amoxicillin and Clavulanic acid (also named Coamoxyclav) is a known drug of having adverse hepatic effects, mainly by three mechanisms: Cholestasis, Hepatocellular injury and Mixed mechanism. The most important predisposing factor is age more than 65, however, history of serious medical illness, liver associated comorbidity, use of other medications, drug dose, route and duration of therapy, smoking or previous use of amoxicillin-clavulanic acid, were not associated with liver disease induced by Co-amoxiclave. Co-amoxiclav can produce a wide range of liver injury including intrahepatic cholestasis without hepatitis, acute hepatocellular injury, and cholestatic hepatitis with hepatocellular necrosis. It can produce cholecystitis-like symptoms. Rarely acute pancreatitis, acute interstitial nephritis and acute lacrimal gland inflammation and sialadenitis with prolonged xerostomia rarely occur simultaneously with cholestatic hepatitis.
Normalization of liver enzymes usually occurs some time between 11.5-18 weeks after discontinuation of drug. Treatment is just supportive. The prognosis is favorable in general. Rarely the liver enzymes remain elevated with resulting chronic liver disease and progression to cirrhosis.
3 to 6 month to normalize? Yeah right. On a healthy liver that is. But not my liver which is still slowly recovering and rebuilding.
What to do? Take liver tonics. Take liver rebuilders like milk thisle and the like. Take apple juice regularly. Take digestive enzymes with pancreatin to assist my liver. Eat beets. Drink wheatgrass juice. Take Vitamin E. Good grief. More expenses.
Drug-induced cholestatic liver disease: http://www.eurekah.com/chapter/325
Mechanism of Bile Formation: http://www.eurekah.com/chapter/307
Dandelion improves bile formation: http://www.herbs4health.net/diuretic/diuretic.html
Explore lecithin. Buy taurine supplements to increase bile formation.